Early detection and treatment of diabetic polyneuropathy: Ellen Lund Schaldemose
Ellen began her PhD project hosted by the Danish Pain Research Center on 1 December 2018.
The project will focus on early detection and treatment of diabetic polyneuropathy. Paradoxical heat sensations, i.e. the feeling of warm during cooling of the skin, and abnormal nerve excitability testing as possible early signs of neuropathy will be investigated.
The development of diabetic polyneuropathy is linked to capillary dysfunction where nitric oxide plays an important role. The effect of nitrate and thereby increased nitric oxide as treatment of early diabetic polyneuropathy will be examined.
"Small fiber neuropathy: Clinical and physiological characteristics with focus on adrenergic dysfunction": Thorsten Kamlarczyk Rasmussen
Thorsten began his PhD project hosted by the Danish Pain Research Center on 1 September 2018.
Autonomic symptoms are often overlooked or overshadowed by the initial symptoms related to the primary disease. With these studies early recognition and subsequently diagnosis of autonomic dysfunction is encouraged by validating easier less time-consuming and more precise investigative methods for the diagnostic process. Hopefully, a detailed phenotypic description of small fiber neuropathy will lead to a better understanding of the mechanisms inducing neuropathic pain and prospectively lead the way for further research.
"Understanding underlying mechanisms of diabetic polyneuropathy": Alexander Gramm Kristensen, MD
Alexander began his PhD project hosted by the Department of Clinical Neurophysiology, Aarhus University Hospital, on 1 September 2016.
Using new neurophysiological methods, patients from the DD2 cohort will be examined. The main goal of the study is to correlate the extent of diabetic neuropathy to the function of specific axonal ion channels. This might lead to an earlier diagnosis of diabetic neuropathy along with a better understanding of the underlying mechanisms.
"Painful diabetic polyneuropathy": Sandra Sif Gylfadottir, MD
Sif began her PhD project hosted by the Danish Pain Research Center on 1 September 2016.
The PhD project will focus on estimating the prevalence and characterizing pain and the underlying mechanisms in painful diabetic neuropathy in patients with type 2 diabetes. Patients from the DD2 cohort will be evaluated with clinical examinations and questionnaires.
"Risk factors for diabetic neuropathy and foot disease in type 2 diabetes – clinical epidemiological studies": Diana Hedevang Christensen, MD
Diana began her PhD project hosted by the Department of Clinical Epidemiology, Aarhus University Hospital, on 1 November 2015.
In her project she will utilise registry data as well as a questionnaire survey from newly-diagnosed type 2 diabetes patients. The main focus of her project is to determine risk factors for developing diabetic neuropathy and related diabetic foot disease in type 2 diabetes patients as well as clarifying the potential disease-modifying role of existing pharmacological therapies. As a component of her project, the validity of diagnosis codes for diabetic neuropathy and diabetic foot disease in the Danish National Registry of Patients will be assessed, and detailed algorithms to provide new ways of identifying diabetic neuropathy and diabetic foot disease in routine clinical care registries will be generated and validated.
"Determinants of diabetic neuropathy": Signe Toft Andersen, MD
Signe defended her PhD thesis entitled Diabetic neuropathy and type 2 diabetes on 3 December 2018. Her project was hosted by the Department of Public Health, Section of General Practice.